Target Target DDR Sub-network Modifier Modifier DDR Sub-network Modification ATM CHK ATM CHK phosphorylation ATM CHK KAT5 GNR|DSB acetylation BRCA1 GR ATM CHK phosphorylation BRCA1 GR ATR CHK phosphorylation BRCA1 GR CHEK2 CHK phosphorylation BRCA1 GR PIAS1 DSB sumoylation BRCA1 GR UBE2T DSB ubiquitination BRCA2 GR CHEK1 CHK phosphorylation BRCA2 GR CHEK2 CHK phosphorylation BRCA2 GR ATM CHK phosphorylation BRCA2 GR ATR CHK phosphorylation CDT1 CHK CUL4A GNR|CHK ubiquitination CHEK1 CHK ATR CHK phosphorylation CHEK2 CHK ATM CHK phosphorylation CLSPN CHK CHEK1 CHK phosphorylation CLSPN CHK ATR CHK phosphorylation CLSPN CHK PLK1 CHK phosphorylation CLSPN CHK CUL1 CHK ubiquitination CLSPN CHK RBX1 CHK ubiquitination DCLRE1B GR ATR CHK phosphorylation DCLRE1B GR ATM CHK phosphorylation DCLRE1C GR ATM CHK phosphorylation DCLRE1C GR PRKDC CHK phosphorylation EXO1 GR ATR CHK phosphorylation FAM175A DSB ATM CHK phosphorylation FAM175A DSB ATR CHK phosphorylation FANCD2 GR ATM CHK phosphorylation FANCD2 GR UBE2T GR ubiquitination FBXO31 CHK ATM CHK phosphorylation H2AFX DSB PRKDC CHK phosphorylation H2AFX DSB ATM CHK phosphorylation H2AFX DSB UBE2N CHK ubiquitination H2AFX DSB RNF168 DSB ubiquitination H2AFX DSB RNF8 DSB ubiquitination H2AFX DSB KAT5 GNR|DSB acetylation HERC2 DSB ATM DSB phosphorylation HNRPK CHK MDM2 CHK ubiquitination MDM2 CHK ATM CHK phosphorylation MDM4 CHK CHEK1 CHK phosphorylation MDM4 CHK CHEK2 CHK phosphorylation MDM4 CHK ATM CHK phosphorylation MAPK3 CHK MAPKAPK2 CHK phosphorylation Cdc25A CHK CHEK1 CHK phosphorylation Cdc25A CHK CHEK2 CHK phosphorylation Cdc25C CHK CHEK1 CHK phosphorylation Cdc25C CHK CHEK2 CHK phosphorylation Cdc25C CHK MAPKAPK2 CHK phosphorylation MSH2 GR ATM CHK phosphorylation MSH2 GR ATR CHK phosphorylation MSH3 GR ATM CHK phosphorylation MSH3 GR ATR CHK phosphorylation MSH6 GR ATR CHK phosphorylation KAT8 GR KAT8 GR acetylation NBN GR|DSB ATM CHK phosphorylation NR4A2 RFN|GR PRKDC CHK phosphorylation PALB2 GR ATM CHK phosphorylation PALB2 GR ATR CHK phosphorylation PRKDC GR PRKDC CHK phosphorylation RAD17 RFN ATM CHK phosphorylation RAD17 RFN ATR CHK phosphorylation RAD50 GR|DSB ATM CHK phosphorylation RAD50 GR|DSB ATR CHK phosphorylation RAD51 GR|DSB CHEK1 CHK phosphorylation RAD9A CHK ATM CHK phosphorylation RAD9A CHK ATR CHK phosphorylation RBBP8 GR ATM CHK phosphorylation RBBP8 GR BRCA1 GR ubiquitination RPA1 RFN ATM CHK phosphorylation RPA1 RFN ATR CHK phosphorylation RPA2 RFN PRKDC CHK phosphorylation RNF168 DSB PIAS4 DSB sumoylation RNF8 DSB PIAS4 DSB sumoylation SMC1A DSB ATM CHK phosphorylation SMC1A DSB ATR CHK phosphorylation SMC5 GR NSMCE2 GR sumoylation SMC6 GR NSMCE2 GR sumoylation TRIM28 CHK ATM CHK phosphorylation TRIM28 CHK CHEK2 CHK phosphorylation TRIM28 CHK CHEK1 CHK phosphorylation TRIM28 CHK TRIM28 CHK sumoylation TIPIN RFN ATR CHK phosphorylation TIPIN RFN ATM CHK phosphorylation TOPB1 CHK UBR5 RFN ubiquitination TRIP12 DSB ATM CHK phosphorylation TRIP12 DSB ATR CHK phosphorylation UBE2T GR UBE2T GR ubiquitination UIMC1 DSB ATM CHK phosphorylation UIMC1 DSB ATR CHK phosphorylation UIMC1 DSB PIAS1 DSB sumoylation WEE1 CHK PLK1 DSB phosphorylation WEE1 CHK CUL1 DSB ubiquitination WEE1 CHK RBX1 CHK ubiquitination XPA GR ATM CHK phosphorylation XPA GR ATR CHK phosphorylation XPA GR SIRT1 GR deacetylation XRCC1 GR PRKDC GR phosphorylation XRCC4 GR PRKDC GR phosphorylation XRCC5 GR PRKDC GR phosphorylation XRCC6 GR PRKDC GR phosphorylation